Biologics

Umbilical-cord biologics

Mesenchymal stem cells and MSC-derived exosomes from equine and human umbilical cord tissue, manufactured to one specification in one facility.

Availability and regulatory channel

No lawful US commercial channel is documented for these products today. They are real, characterised and manufacturable; the route to market is not yet established. Until it is, we publish the specification and the release panel and we do not publish a price or an order button.

The evidence, precisely

What has actually been shown

In a multicentre, double-blind, randomised, placebo-controlled trial of 80 client-owned dogs with naturally occurring elbow or hip osteoarthritis, a single intra-articular injection of equine umbilical-cord MSCs improved force-plate gait analysis in 63% of dogs at eight weeks, with 77% improved on orthopaedic examination.

Punzón et al., J Am Vet Med Assoc 2022;260(15):1947–1955. PMID 36198051

Why we do not borrow the secretome trials

Results from one preparation cannot be carried to another. Micro-fragmented adipose tissue, stromal vascular fraction, platelet-rich plasma, conditioned medium, secretome, purified exosomes and culture-expanded stem cells are different products with different evidence. The two randomised canine trials are SECRETOME trials, not purified-exosome trials. In a canine demyelination model stem cells outperformed stem-cell-derived exosomes, and in equine tendon cells whole conditioned medium produced a larger response than its isolated vesicle fraction. So we do not present those trials as evidence for our own purified exosome line.

PMID 38459498; PMID 37446034

On immune response

In a randomised safety trial in dogs, both equine and canine MSCs raised antibody titres, with no adverse events after single or repeated administration. Umbilical-cord MSCs are immune-evasive, not immune-invisible — and we will not tell you otherwise.

Punzón et al., Front Vet Sci 2023;10:1098029. PMID 37266387

Regulatory status. The cell- and exosome-based products described on this site are not approved by the FDA for use in animals. In the United States they are unapproved new animal drugs. Nothing on this site is a diagnosis, a treatment recommendation, or a substitute for examination by a licensed veterinarian. Product information is directed to veterinary professionals. Pricing and ordering are available only to clinics with a verified licence.

Exosome line

Canine / Feline Exosome — Equine UC-MSC derived

CA-EXO-1-EQ · dog, cat

Equine-derivedEarly evidenceChannel pending

1 mL, ~2 × 10⁹ particles, standard release panel

Derived from the same umbilical-cord source species as the only EMA-authorised veterinary MSC medicine.

Fill: 1 mL
Content: ~2 × 10⁹ particles (NTA)
Storage: Cryopreserved, shipped on dry ice overnight. Store at -80 °C on arrival.

Not FDA-approved, not conditionally approved, and not on FDA CVM's risk-reviewed list of animal cell- and tissue-based products.

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Canine / Feline Exosome — Human UC-MSC derived

CA-EXO-1-HU · dog, cat

Human-derivedEarly evidenceChannel pending

1 mL, ~2 × 10⁹ particles, standard release panel

Fill: 1 mL
Content: ~2 × 10⁹ particles (NTA)
Storage: Cryopreserved, shipped on dry ice overnight. Store at -80 °C on arrival.

Not FDA-approved, not conditionally approved, and not on FDA CVM's risk-reviewed list of animal cell- and tissue-based products.

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Canine / Feline Exosome Extended — Equine UC-MSC derived

CA-EXO-1X-EQ · dog, cat

Equine-derivedEarly evidenceChannel pending

1 mL, ~5 × 10⁹ particles, extended release panel

Fill: 1 mL
Content: ~5 × 10⁹ particles (NTA)
Storage: Cryopreserved, shipped on dry ice overnight. Store at -80 °C on arrival.

Not FDA-approved, not conditionally approved, and not on FDA CVM's risk-reviewed list of animal cell- and tissue-based products.

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Canine / Feline Exosome Extended — Human UC-MSC derived

CA-EXO-1X-HU · dog, cat

Human-derivedEarly evidenceChannel pending

1 mL, ~5 × 10⁹ particles, extended release panel

Fill: 1 mL
Content: ~5 × 10⁹ particles (NTA)
Storage: Cryopreserved, shipped on dry ice overnight. Store at -80 °C on arrival.

Not FDA-approved, not conditionally approved, and not on FDA CVM's risk-reviewed list of animal cell- and tissue-based products.

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Equine Exosome — Equine UC-MSC derived

EQ-EXO-5-EQ · horse

Equine-derivedEarly evidenceChannel pending

5 mL per joint, ~5 × 10⁹ particles, standard release panel

Fill: 5 mL
Content: ~5 × 10⁹ particles (NTA)
Storage: Cryopreserved, shipped on dry ice overnight. Store at -80 °C on arrival.

Not FDA-approved, not conditionally approved, and not on FDA CVM's risk-reviewed list of animal cell- and tissue-based products.

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Equine Exosome — Human UC-MSC derived

EQ-EXO-5-HU · horse

Human-derivedEarly evidenceChannel pending

5 mL per joint, ~5 × 10⁹ particles, standard release panel

Fill: 5 mL
Content: ~5 × 10⁹ particles (NTA)
Storage: Cryopreserved, shipped on dry ice overnight. Store at -80 °C on arrival.

Not FDA-approved, not conditionally approved, and not on FDA CVM's risk-reviewed list of animal cell- and tissue-based products.

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Equine Exosome Extended — Equine UC-MSC derived

EQ-EXO-5X-EQ · horse

Equine-derivedEarly evidenceChannel pending

5 mL per joint, ~15 × 10⁹ particles, extended release panel

Fill: 5 mL
Content: ~15 × 10⁹ particles (NTA)
Storage: Cryopreserved, shipped on dry ice overnight. Store at -80 °C on arrival.

Not FDA-approved, not conditionally approved, and not on FDA CVM's risk-reviewed list of animal cell- and tissue-based products.

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Equine Exosome Extended — Human UC-MSC derived

EQ-EXO-5X-HU · horse

Human-derivedEarly evidenceChannel pending

5 mL per joint, ~15 × 10⁹ particles, extended release panel

Fill: 5 mL
Content: ~15 × 10⁹ particles (NTA)
Storage: Cryopreserved, shipped on dry ice overnight. Store at -80 °C on arrival.

Not FDA-approved, not conditionally approved, and not on FDA CVM's risk-reviewed list of animal cell- and tissue-based products.

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MSC line

Canine / Feline UC-MSC — Equine derived

CA-MSC-1-EQ · dog, cat

Equine-derivedControlled trial in this speciesChannel pending

1 mL, 10–20 × 10⁶ UC-MSC, intra-articular

This is the grade and route matching the published randomised controlled trial in dogs with naturally occurring elbow or hip osteoarthritis.

Fill: 1 mL
Content: 10–20 × 10⁶ cells
Storage: Cryopreserved, shipped on dry ice overnight. Store at -80 °C on arrival.

Not FDA-approved, not conditionally approved, and not on FDA CVM's risk-reviewed list of animal cell- and tissue-based products.

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Canine / Feline UC-MSC — Human derived

CA-MSC-1-HU · dog, cat

Human-derivedEarly evidenceChannel pending

1 mL, 10–20 × 10⁶ UC-MSC, intra-articular

Fill: 1 mL
Content: 10–20 × 10⁶ cells
Storage: Cryopreserved, shipped on dry ice overnight. Store at -80 °C on arrival.

Not FDA-approved, not conditionally approved, and not on FDA CVM's risk-reviewed list of animal cell- and tissue-based products.

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Equine UC-MSC — Equine derived

EQ-MSC-2-EQ · horse

Equine-derivedEarly evidenceChannel pending

2 mL per joint, 20–40 × 10⁶ UC-MSC

Off-the-shelf: no prior banking and no owner pre-enrolment required.

Fill: 2 mL
Content: 20–40 × 10⁶ cells
Storage: Cryopreserved, shipped on dry ice overnight. Store at -80 °C on arrival.

Not FDA-approved, not conditionally approved, and not on FDA CVM's risk-reviewed list of animal cell- and tissue-based products.

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Equine UC-MSC — Human derived

EQ-MSC-2-HU · horse

Human-derivedEarly evidenceChannel pending

2 mL per joint, 20–40 × 10⁶ UC-MSC

Fill: 2 mL
Content: 20–40 × 10⁶ cells
Storage: Cryopreserved, shipped on dry ice overnight. Store at -80 °C on arrival.

Not FDA-approved, not conditionally approved, and not on FDA CVM's risk-reviewed list of animal cell- and tissue-based products.

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About the two grades

Why the human-derived grade costs more:

Human perinatal tissue procurement operates inside a deeper donor screening, serology and NAT framework, with donor-eligibility records retained.
Larger single-donor lots mean more doses share one release-test panel, so lot-to-lot variation within a single purchase is lower.
Allocation is constrained.

No head-to-head comparison of human-derived and equine-derived umbilical-cord products has been performed in dogs, cats or horses. The price difference reflects donor screening, lot size and documentation, not a demonstrated difference in clinical effect.

The equine-derived grade is the one with a randomised controlled trial in dogs. It is not a budget option, and we do not describe it as one.

Evidence against our own premium grade

The only head-to-head comparison of perinatal MSC extracellular vesicles found fetal-derived vesicles induced more robust transcriptional changes than perinatal-derived ones, and concluded that donor cell age mattered more than cell type. Human perinatal vesicles were the weaker performers in that study. We publish this because it runs against our own premium grade.

Tarasova K et al., Stem Cell Res Ther 2025;16(1):478. PMID 40890860

MSC release panel

Viability (≥ 80% post-thaw)
Cell count
ISCT surface-marker panel by flow cytometry
Tri-lineage differentiation (lot qualification)
Sterility (USP <71>)
Endotoxin (USP <85>)
Mycoplasma
Karyotype / genomic stability

Exosome release panel (extended)

Particle count and size distribution by NTA
Tetraspanin markers (CD9 / CD63 / CD81)
Total protein
Sterility (USP <71>)
Endotoxin (USP <85>)
Mycoplasma
Particle:protein purity ratio
Absence markers (calnexin)
Functional potency surrogate
Residual-reagent assay

Characterisation follows the MISEV framework for extracellular-vesicle reporting.

Ordering is licence-verified

Pricing, lot COAs and ordering live inside the clinic portal. We verify a veterinary licence before the catalogue opens.

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